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Desmethylanethol trithione
CAS No. 18274-81-2
Desmethylanethol trithione( ADT-OH | Desmethylanethol trithione | ACS1 )
Catalog No. M17391 CAS No. 18274-81-2
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
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| 10MG | 51 | In Stock |
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| 25MG | 88 | In Stock |
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| 50MG | 149 | In Stock |
|
| 100MG | 239 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDesmethylanethol trithione
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NoteResearch use only, not for human use.
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Brief DescriptionADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor.
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DescriptionADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following stroke.
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In Vitro——
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In Vivo——
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SynonymsADT-OH | Desmethylanethol trithione | ACS1
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PathwayPI3K/Akt/mTOR signaling
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TargetS6 Kinase
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RecptorAkt| VEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number18274-81-2
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Formula Weight226.33
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Molecular FormulaC9H6OS3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (552.27 mM)
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SMILESc1cc(O)ccc1c1cc(=S)ss1
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Chemical Name5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hasegawa U,et al. Hydrolysis-Sensitive Dithiolethione Prodrug Micelles. Macromol Biosci. 2015 Nov;15(11):1512-22.
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